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自闭症症状严重程度与视听语音感知功能神经成像测量之间的关联

Lars A Ross¹, Sophie Molholm², John J Foxe²

¹The Frederick J. and Marion A. Schindler Cognitive Neurophysiology Laboratory, The Ernest J. Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Department of Imaging Sciences, University of Rochester Medical Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; The Cognitive Neurophysiology Laboratory, Departments of Pediatrics and Neuroscience, Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, NY 10461, USA.

NeuroImage. Clinical

|February 21, 2026

概括

患有自闭症谱系障碍的人对视觉语音暗示的益处较小,特别是在噪音中. 较高的症状严重程度与多感官语音处理受损和语言区域大脑活动改变有关.

科学领域:

神经科学是一个神经科学.
语音和听力科学语言和听力科学
发展心理学发展心理学

背景情况:

自闭症谱系 (ASD) 个体经常表现出听觉处理方面的挑战,特别是在杂的环境中.
视觉关节线索通常有助于语音感知,但它们的好处可能会在ASD中减少.

研究的目的:

调查自闭症谱系障碍症状严重程度如何与视听语言信息的处理有关.
确定多感官语音感知缺陷是否与更广泛的ASD症状有关.

主要方法:

对32名ASD患者进行了一项行为语音噪音任务.
一项功能神经成像研究检查了37名ASD个体在视听语言任务期间的大脑活动.
用校准的症状严重程度得分 (CSS) 来量化症状严重程度.

主要成果:

较差的视听语音表现与较高的CSS相关,但仅听觉表现不受影响,表明特定的多感官 (MS) 处理缺陷.
较高的症状严重程度与在视听刺激期间脑背部语音和语言区域的MS增长减少相关.
探索性分析表明,与典型的发育个体相比,ASD患者的言语运动区域的非典型参与.

结论:

多感官处理缺陷是自闭症谱系障碍的有效特征,可能与核心症状有关.
自闭症症状的严重程度会影响个体如何整合视觉和听觉语音信息以及相关的神经活动.
研究结果表明,大脑如何利用语音运动区域来对ASD的语音知觉有潜在的差异.

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相关概念视频

Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.