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Updated: Feb 23, 2026

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
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走向4D打印的功能性软组织

Amal Shabazz1, Julia Fitlin1, Henry Orozco-Contreras1

  • 1Fischell Department of Bioengineering, University of Maryland, College Park, MD; Center for Engineering Complex Tissues, University of Maryland, College Park, MD.

Acta biomaterialia
|February 21, 2026
PubMed
概括
此摘要是机器生成的。

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4D打印通过创建模仿本地组织的动态,功能结构来增强软组织工程. 本综述探讨了4D打印软组织的进展,解决了未来再生医学应用的挑战.

科学领域:

  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.
  • 组织工程是组织工程.

背景情况:

  • 软组织缺陷的修复是一个重大的临床挑战,特别是对于活跃的个人,创伤患者和与年龄有关的疾病患者.
  • 传统的3D打印创造了静态的组织结构,但长期解决方案需要动态,功能模仿本地人类组织.
  • 4D打印,它结合了时间依赖的执行,为工程功能软组织结构提供了一个有希望的策略.

研究的目的:

  • 审查软组织工程的4D打印技术的技术进步.
  • 探索4D材料启动的机制及其在响应性组织模拟器中的应用.
  • 讨论工程功能4D打印软组织在各种类型 (皮肤,心血管,神经,肌肉,结合性) 的进展,局限性和未来的挑战.

主要方法:

  • 审查增材制造和软组织结构的4D打印技术进步.
  • 对响应外部刺激的4D材料激活机制的分析.
  • 按类型对工程功能软组织的进展和局限性的分类和讨论.

主要成果:

  • 4D打印可以通过将材料操作与增材制造相结合,创建具有时间依赖功能的复杂软组织结构.
  • 在使用4D打印策略设计功能性皮肤,心血管,神经,骨肌肉和结缔组织方面取得了重大进展.
关键词:
通过3D打印打印3D打印.4D打印是一种4D打印.生物制造是生物制造的方法.再生医学是一种再生医学.组织工程是组织工程.

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  • 在为下一代4D打印软组织平衡生物功能与可编程材料特性方面,仍然存在挑战.

    • 结论:

    • 4D打印在软组织工程中比3D打印具有显著的进步,4D打印在软组织工程中比3D打印具有显著的进步,使动态和功能组织模拟器的开发成为可能.
    • 需要进一步的研究来克服制造方面的挑战,并充分实现4D打印软组织在临床应用中的潜力.
    • 本综述强调了未来发展的关键领域,即为再生医学创建复杂,响应敏捷的软组织结构.