RIFM香水成分安全性评估,eicosane,CAS注册编号为112-95-8 香水成分安全性评估,eicosane,CAS注册编号为112-95-8
A M Api1, A Bartlett1, D Belsito2
1Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ 07430, USA.
概括
埃科桑是安全的使用,在毒性,敏感性或环境影响评估中没有表现出基因毒性或重大风险. 关键毒性终点的安全率超过100,证实了其安全性.
科学领域:
- 毒理学 毒理学 毒理学
- 环境安全 环境安全
- 化学安全评估 化学安全评估
背景情况:
- 伊可是一种长链基,具有各种工业应用.
- 全面的安全评估对于了解潜在的人类健康和环境影响至关重要.
研究的目的:
- 评估eicosane的基因毒性,重复剂量毒性,生殖毒性,局部呼吸系统毒性,光刺激/光过敏性,皮肤敏感性和环境安全性.
- 为了确定eicosane在目前的使用水平下是否存在任何安全问题.
主要方法:
- 利用从类似物,如 heneicosane,undecane,paraffin的毒性终点的阅读交叉数据.
- 根据染色体结构分析评估的光刺激/光过敏性.
- 使用毒理关注门 (TTC) 评估局部呼吸道毒性.
- 通过评估持久性,生物积累和毒性 (PBT) 标准和计算风险系数 (RQs) 来确定环境安全.
主要成果:
- 埃科桑没有表现出任何基因毒性.
- 通过交叉阅读,重复剂量和生殖毒性暴露边际 (MOE) 超过100.
- 没有发现皮肤敏感化的安全问题.
- 埃科桑缺乏染色体,表明没有光刺激或光过敏性风险.
- 当地呼吸道暴露低于TTC.
- 埃科桑不是持久性,生物积累性和有毒性 (PBT),在全球主要地区的RQ为<1.
结论:
- 埃科桑不是基因毒性,并且对重复剂量或生殖毒性没有显著的安全问题.
- 该物质不是光刺激剂或光敏感剂,也不会造成皮肤敏感化的风险.
- 环境风险评估证实eicosane不是PBT,并且在目前的使用量下对环境的影响是可以忽略不计的.
相关概念视频
02:28Structure and Nomenclature of Ethers
Structure and Bonding
Ethers are organic compounds with an ether functional group which is characterized by an oxygen atom connected to two — identical or different — alkyl, aryl, or vinyl groups. The C–O–C linkage in dimethyl ether — the simplest ether — has an approximately tetrahedral bond angle of 110.3 degrees. The oxygen atom is sp3- hybridized, with the C–O distance being about 140 pm.
Classification of Ethers
Based on their attached substituent groups, ethers can be classified into two...
Ethers are organic compounds with an ether functional group which is characterized by an oxygen atom connected to two — identical or different — alkyl, aryl, or vinyl groups. The C–O–C linkage in dimethyl ether — the simplest ether — has an approximately tetrahedral bond angle of 110.3 degrees. The oxygen atom is sp3- hybridized, with the C–O distance being about 140 pm.
Classification of Ethers
Based on their attached substituent groups, ethers can be classified into two...
02:28Cycloalkanes
Cycloalkanes are saturated cyclic hydrocarbons with carbon atoms arranged in the form of rings. They have two fewer hydrogen atoms than the corresponding acyclic alkane; therefore, their general formula is CnH2n. The structural formulas of cycloalkanes are simplified using the line-angle representation. The regular polygons are used to represent the cycloalkane rings, with each side representing a carbon-carbon bond.
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
02:33Stereoisomerism of Cyclic Compounds
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
02:38Structure and Nomenclature of Epoxides
Cyclic ethers are heterocyclic compounds with an oxygen atom in the ring along with carbon atoms. They are named depending on the number of carbon atoms present in their ring system. Cyclic ethers with a three-membered ring system are called “oxirane”, four-membered ring systems as “oxetane”, five-membered ring systems as “oxolane”, and six-membered ring systems as “oxane”. The cyclic structure of these rings imposes angle strain, and this strain is more in the ring having a smaller number of...
01:29UV–Vis Spectroscopy: Woodward–Fieser Rules
UV–Visible absorption spectra of conjugated dienes arise from the lowest energy π → π* transitions. The light-absorbing part of the molecule is called the chromophore, and the substituents directly attached to the chromophore are called auxochromes. A strong correlation exists between the absorption maxima, λmax, and the structure of a conjugated π system. The Woodward–Fieser rules predict the value of λmax for a given structure by adding the contributions...
01:05Mass Spectrometry: Cycloalkane Fragmentation
In mass spectrometry, cycloalkanes exhibit distinct fragmentation patterns due to the inherent stability of their molecular ions compared to linear or branched alkanes. The ring structure of cycloalkanes provides additional stability to the molecular ions, often resulting in prominent ion peaks in the mass spectrum.
For example, cyclohexane molecular ions have a mass-to-charge ratio (m/z) of 84, which tends to produce a stronger signal than linear alkanes like hexane. This stability comes from...
For example, cyclohexane molecular ions have a mass-to-charge ratio (m/z) of 84, which tends to produce a stronger signal than linear alkanes like hexane. This stability comes from...