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基于ERCP的儿科慢性胰腺炎的治疗:从回顾性长期多中心研究的结果
Simona Faraci1, Giovanni Rollo1, Federico Alghisi2
1Gastroenterology and nutrition Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
概括
内镜逆行胆血管瘤造影 (ERCP) 有效地减少慢性胰腺炎的儿童急性胰腺炎的发作. 这种程序可以通过减少症状复发来改善他们的生活质量.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 干预性内镜检查是干预性的内镜检查.
背景情况:
- 儿童慢性胰腺炎 (CP) 会导致重复的急性发作和逐渐的胰腺功能障碍.
- 内镜逆行性胆血管细胞造影 (ERCP) 用于管理CP的管道问题,但儿科证据很少.
研究的目的:
- 评估基于ERCP的治疗对患有遗传相关性CP的儿科患者的疗效和安全性.
- 评估ERCP对这一群体胰腺炎复发率的影响.
主要方法:
- 一项多中心的回顾性研究包括了接受ERCP的基因相关的CP儿童.
- 在ERCP之前和之后收集和比较了临床程序,结果和胰腺炎发病率的数据.
主要成果:
- 42名儿科患者接受了ERCP,平均每人接受4.5次手术.
- 不管支架安置如何,ERCP显著减少了急性胰腺炎的发作 (PIRpre 4.6与PIRpost 1.1相比,p = 0.0024).
- 在ERCP后的胰腺炎 (PEP) 发生在14.2%的手术中,大多是轻微的;并发症很少见,并以保守的方式管理.
结论:
- ERCP是一种安全有效的治疗方法,可减少患有遗传相关的胰腺炎的儿童胰腺炎复发.
- 这些发现表明,ERCP可能会提高这些年轻患者的生活质量.
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