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巨细胞衍生的神经生长因子驱动膀癌中的ILC2前瘤功能

Maryline Falquet1,2,3,4,5, Hajar El Ahanidi1,2,3,4,5, Alejandra Gomez-Cadena1,2,3,4,5

  • 1Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Nature communications
|February 21, 2026
PubMed
概括

神经生长因子 (NGF) 在膀癌中驱动2型先天性淋巴细胞 (ILC2s) 的前瘤功能. 阻断NGF受体TrkA可以提高生存率,并在临床前模型中增强免疫治疗反应.

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