跨精神和身体疾病系统的共同遗传责任
Jeremy M Lawrence1,2, Isabelle F Foote3, Sophie Breunig3,4
1Institute for Behavioral Genetics, University of Colorado Boulder, 1480 30th Street, Boulder, CO, 80303, USA. Jeremy.Lawrence@colorado.edu.
Nature communications
|February 21, 2026
概括
精神疾病和身体疾病之间的遗传联系是常见的. 具体的精神病学因素,如内化和神经发育,与许多身体条件显著分享遗传风险,建议新的诊断方法.
科学领域:
- 精神病学遗传学 精神病学遗传学
- 流行病学 流行病学
- 基因组分析 基因组分析
背景情况:
- 广泛的精神-身体并发症被记录在案.
- 这种并发性疾病的跨诊断性质需要进一步调查.
- 基因组 SEM (结构方程建模) 是一种分析遗传相关性的工具.
研究的目的:
- 研究精神和身体健康状况的跨诊断遗传基础.
- 将基因组SEM扩展为一种探索性方法 (基因组E-SEM),用于分析物理结果.
- 在精神病和身体疾病领域之间识别共同的遗传风险因素.
主要方法:
- 应用基因组SEM和小说基因组E-SEM对73个物理结果,来自8个医疗领域的约190万例病例.
- 模拟了潜在的身体疾病因素与已确定的精神病因素一起.
- 在一个跨诊断的身体疾病因素上进行了多变量基因组广泛关联研究 (GWAS).
主要成果:
- 内化,神经发育和物质使用的精神病学因素表明了与所有身体疾病系统的大量基因组范围的遗传相关性.
- 思想/精神病和强迫因素与身体疾病因素的联系有限.
- 一个跨诊断的身体疾病因子,包括21种疾病,确定了27个基因组风险位点,并在PheWAS (Phenome-Wide Association Studies) 中显示出强大的预测有效性.
结论:
- 在特定的精神病群体 (内化,神经发育,物质使用) 和身体条件之间揭示了普遍的遗传风险共享.
- 研究结果表明,需要修订超越当前诊断类别的鼻科框架.
- 突出了基因组方法的潜力,以揭示精神和身体健康之间的共同病因.
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