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Updated: Feb 23, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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RORγt+APCs需要一个不同的cis-regulatory元素来指导对饮食抗原的耐受性

Jie Zhao1,2,3,4, Jiacheng Hao1,2,3,4, Jincheng Chen1,2,3,4

  • 1Institute for Immunology, Tsinghua University, Beijing, China.

Nature communications
|February 21, 2026
PubMed
概括

一个新发现的调节元件,OCR369,控制抗原呈现细胞 (APC) 中的RORγt表达,这对口服耐受性至关重要. 它的删除会损害Treg的发育,导致肠道炎症和增加过敏敏感性.

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