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Updated: Feb 23, 2026

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
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由ND4 G11778A突变介导的氧化应激失衡和细胞损伤

Lijun Fang1, Kangyue Fu2, Mengyu Yang2

  • 1Department of Ophthalmology, Fujian Medical University Union Hospital, No. 29, Xinquan Road, Fuzhou, 350001, Fujian, China.

Scientific reports
|February 21, 2026
PubMed
概括

MT-ND4突变 (m.11778G>A) 损害了线粒体功能,降低了氧气消耗和抗氧化能力. 这导致反应性氧物种增加和细胞损伤,导致视神经退化.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.细胞损伤 细胞损伤勒贝尔遗传性视神经病变 (Leber hereditary optic neuropathy) 是一种遗传性的视神经病变.线粒体中的线粒体.氧化酸化是一种氧化酸化.氧化应激是一种氧化应激.

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