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Updated: Feb 23, 2026

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models
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Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models

Published on: November 21, 2015

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对小肠小鼠Lgr5+细胞群的单核多基因分析揭示了Foxa3诱导的Paneth细胞系分化

Xinran Deng1,2,3, Shenfei Sun1,4, Chenqi Lu1

  • 1State Key Laboratory of Genetics and Development of Complex Phenotypes, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Life Sciences, Fudan University, Shanghai, China.

Communications biology
|February 21, 2026
PubMed
概括

肠道中的Lgr5+干细胞显示出令人惊的多样性. 研究人员确定Foxa3是通过PPARs调节帕内斯细胞分化的关键因素,改善了对肠道发育和疾病的理解.

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Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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