由mNGS发现的由Mycobacterium结核病引起的耐药腹膜透析相关腹膜炎:一个病例报告
Lichun Wang1, Junjie Xu2, Peihua He3
1Department of Nephrology, Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 53 Jida Jingle Road, Xiangzhou District, Zhuhai, Guangdong Province, 519015, China. wanglichun322@163.com.
BMC nephrology
|February 21, 2026
概括
结核相关的腹膜炎是腹膜透析患者的罕见并发症. 基因组测序在培养基呈阴性时有助于诊断,使得及时的抗结核治疗和成功的治疗延续成为可能.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 腹膜透析相关的腹膜炎 (PDAP) 是腹膜透析 (PD) 的常见并发症.
- 肺结核相关腹膜炎 (TRP) 在PD患者中不常见,表现为非特异性症状,常常在常规诊断测试中呈阴性.
- 早期诊断和治疗TRP至关重要,以防止技术失败和改善患者的治疗结果.
研究的目的:
- 在接受维持腹腔透析的患者中报告与结核有关的腹腔炎病例.
- 为了突出与这种罕见疾病相关的诊断挑战.
- 评估元基因组下一代测序 (mNGS) 作为诊断工具的实用性.
主要方法:
- 本文介绍了一个34岁女性患有PD末期脏病的病例报告.
- 患者表现出发烧,腹痛和腹的症状,常规培养基呈阴性.
- 进行了腹膜透析废水的下一代元基因组测序.
主要成果:
- 传统的PD废水和血液的细菌和真菌培养是负的.
- 下一代元基因组测序确定了PD废水中的Mycobacterium结核病.
- 抗结核治疗导致症状缓解,允许暂时暂停并随后恢复PD.
结论:
- 与结核病相关的腹膜炎在PD患者中带来了重大诊断挑战.
- 下一代元基因组测序可以成为一种有价值的辅助工具,用于在传统方法失败时诊断TRP.
- 这种分子技术可以促进早期诊断和适当的管理,改善结果.
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