协调多功能性和 Co2+,Cu2+ 和 Cd2+ 复合物的增强生物活性,这些复合物来自于皮里迪尔希夫基:结构,电子和电化学见解
Abrar K Elshewemy1, Esam A Gomaa1, Hamed M Abou El Nadar1
1Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.
BMC chemistry
|February 21, 2026
概括
一个新的希夫基联结体及其,铜和复合物被合成和特征化. 这些化合物显示出有前途的抗菌,抗真菌,抗氧化,DNA结合和抗癌活性.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
背景情况:
- 希夫基是协调化学中的多功能连接体.
- 与自由连接体相比,金属复合体往往表现出增强的生物活性.
研究的目的:
- 合成和描述一个新的希夫基联体及其Co (II),Cu (II) 和Cd (II) 复合体.
- 研究合成化合物的结构,光谱,电化学和生物特性.
主要方法:
- 希夫基合成的冷凝反应.
- 与金属离子的复合.金属离子.
- 进行光谱 (FT-IR,UV-Vis,NMR,ESR) 和显微 (PXRD,TEM) 分析.
- 物理化学 (CHN,导电,热) 分析.
- 密度函数理论 (DFT) 的计算.
- 循环电压计. 循环电压计.
- 生物分析 (抗菌,抗真菌,抗氧化剂,DNA结合,细胞毒性).
主要成果:
- 为复合体确定了单核八面体和双核正方形平面几何形状.
- DFT研究支持实验性光谱和反应性趋势.
- 电化学分析显示了准可逆/不可逆的行为.
- 希夫基及其金属复合物表现出显著的抗菌,抗真菌,抗氧化,DNA结合,以及对HepG2和MCF-7细胞系进行体内细胞毒性活动.
结论:
- 合成的希夫基联体及其金属复合物具有多种协调模式,并表现出有前途的生物活动.
- 这些发现凸显了这些化合物作为治疗剂和材料科学应用中的潜力.
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