自然生物活性分子和化疗药物的协同作用,用于增强癌症治疗
Mehrdad Hashemi1,2, Katayoun Heshmatzad3, Ghazaleh Shahsavan1
1Farhikhtegan Medical Convergent Sciences Research Center, Farhikhtegan Hospital, Faculty of Medicine, TeMs.C., Islamic Azad University, Tehran, Iran.
自然化合物可以提高化疗的有效性并减少副作用. 本综述探讨了这些生物活性物质,如多,如何改善癌症治疗结果和患者耐受性.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 化疗对于癌症治疗至关重要,但面临着药物耐药性和毒性等挑战.
- 寻求辅助策略来提高化疗疗效和患者耐受性.
- 天然生物活性化合物作为常规化疗的辅助剂具有潜力.
研究的目的:
- 审查天然生物活性化合物作为化疗辅助剂.
- 为提高疗效和抗性调节划出作用机制.
- 总结关于组合疗法的临床前和临床数据.
- 评估天然化合物的潜力,以减轻化疗引起的器官毒性.
主要方法:
- 临床前和临床研究的文献综述.
- 通过自然生物活性物调节的分子通路的分析.
- 对抗化疗引起的毒性对器官保护作用的检查.
主要成果:
- 自然生物活性物调节关键的癌症通路 (NF-κB,PI3K/AKT/mTOR,NRF2/HO-1),以增强化疗敏感性和亡.
- 在临床前模型中,黄素与5-甲和复星与西斯普拉丁等组合显示出改善的抗瘤活性和降低毒性.
- 化合物表明器官保护心脏毒性,毒性,神经毒性和胃肠道损伤.
结论:
- 将天然生物活性与化疗相结合,通过增强抗瘤效果和减少毒性,提高治疗指数.
- 进一步的临床验证和标准化质量控制对于这些天然化合物的常规采用是必要的.
- 天然化合物是改善癌症治疗效率和患者生活质量的有希望的策略.
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