饮食中的多不和脂肪酸与风湿性关节炎患者心血管疾病之间的关联
Danxuan Huang1, Peiyu Wu1, Yilan Chen1
1Department of Rheumatology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, People's Republic of China.
European journal of medical research
|February 21, 2026
概括
较高的林诺酸 (LA) 和n-6多不和脂肪酸 (PUFA) 摄入量与风湿性关节炎 (RA) 患者心血管疾病 (CVD) 风险增加有关. 特定的食脂肪酸可能会影响RA中的心血管疾病,需要进一步研究营养指导.
科学领域:
- 营养科学 营养科学
- 类风湿病学 类风湿病学
- 心血管健康 心血管健康
背景情况:
- 类风湿性关节炎 (RA) 是一种自身免疫性炎症状况,与心血管疾病 (CVD) 风险增加有关.
- 在RA患者中,饮食中的多不和脂肪酸 (PUFA) 和心血管疾病之间的关系尚不清楚.
研究的目的:
- 研究在被诊断为RA的个人中,PUFA消费与心血管疾病患病率之间的关联.
- 使用来自2007-2018年国家健康和营养检查调查 (NHANES) 的数据.
主要方法:
- 对1394名RA患者的横截面分析.
- 通过24小时的饮食回忆评估的PUFA摄入量.
- 用于分析PUFA-CVD关系的物流回归模型,对共变量进行调整.
主要成果:
- 较高的乙酸 (EPA) 摄入量显示了与心血管疾病的初步反向关联,在完全调整后失去意义.
- 增加林诺基酸 (LA) 和n-6PUFA的摄入量与更高的心血管疾病患病率有关.
- 对于其他n-3PUFAs,没有发现显著的关联;剂量反应分析没有产生一致的显著非线性关系.
结论:
- 增加LA和n-6PUFA的摄入量与RA患者心血管疾病患病率的增加有关.
- 饮食脂肪酸概况可能在RA患者心血管疾病风险中起作用.
- 需要进一步的研究来确定因果关系,并制定有针对性的营养策略.
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