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基于舞蹈的途径,以推进化疗效应的非药物治疗 (DAANCE):多中心随机对照试验的研究协议

Bhillie D Luciani¹, Aya Alwan¹, Martha Carlson¹

¹Department of Physical Medicine and Rehabilitation, College of Medicine, The Ohio State University, Columbus, 43210, OH, USA.

|February 21, 2026

概括

适应的阿根廷探戈可以改善乳腺癌幸存者的化疗诱导的神经病变 (CIN) 症状. 这种体力活动干预措施有望增强感觉和功能,提供一种非药物治疗方法来管理衰弱的副作用.

科学领域:

神经学和瘤学是神经学和瘤学.
康复和物理治疗治疗.

背景情况:

乳腺癌 (BC) 幸存者经常经历化疗诱导的神经病变 (CIN),导致感官和功能缺陷.
目前用于CIN的药理疗法具有有限的疗效和不良副作用.
正在探索体力活动 (PA) 作为一种非药物治疗方法来管理CIN症状.

研究的目的:

评估适应阿根廷探戈 (Tango) 作为一种基于PA的治疗乳腺癌幸存者的CIN的效果.
评估Tango与标准护理 (SOC) 相比对患者报告的结果和功能性措施的干预效应.

主要方法:

一个多中心,前性,随机对照试验与可选的交叉.
参与者被随机分配到Tango干预或SOC主动对照.
主要结局:患者报告的感觉变化从基线到4周;次要结局:疲劳,平衡,步态和上肢功能.

主要成果:

该研究假设,与SOC相比,4周的坦哥练习会显著改善感觉和功能.
探索性措施包括姿势控制,步态稳定,认知负荷和血液生物标志物.
将使用线性混合模型来分析测量结果的变化.

结论:

阿根廷探戈,涉及体力活动,听觉运动和社会参与,被假设可以显著改善CIN症状.
这些发现可能会支持Tango作为一种安全的非药物干预措施,用于改善乳腺癌幸存者的CIN相关缺陷.
这项研究可能会导致新的治疗策略,用于管理癌症治疗的长期副作用.

关键词:

生物力学生物力学化疗引起的神经病变.舞蹈舞蹈舞蹈舞蹈舞蹈音乐音乐音乐音乐神经康复疗法神经康复疗法在瘤学瘤学.

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