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表观遗传调制以克服胰腺癌中免疫抑制的作用

Laura Drndakova¹, Lucia Juhasikova¹, Ivana Hlavenova¹

¹Biomedical Research Center, Slovak Academy of Sciences, Dubravska Cesta 9, Bratislava, 84505, Slovakia.

Clinical epigenetics

|February 21, 2026

概括

表观遗传失调驱动胰腺癌 (PDAC) 免疫逃避. 表观遗传疗法可以重新编程瘤微环境 (TME),以增强抗PDAC免疫力和药物输送.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

胰腺管道腺癌 (PDAC) 是一种致命的癌症,其特征是纤维化和免疫抑制瘤微环境 (TME).
表观遗传失调显著导致PDAC进展,免疫逃避和对治疗的抵抗,通过改变对瘤-免疫相互作用和 stromal 重塑至关重要的基因表达.

研究的目的:

审查异常表观遗传机制在PDAC进展和免疫抵抗中的作用.
综合当前对表观遗传改变如何制造治疗和免疫监测障碍的理解.
讨论表观遗传疗法的潜力,单独或组合,以克服PDAC TME驱动的耐药性.

主要方法:

对目前对PDAC表观遗传机制的洞察力进行文献综述.
分析表观遗传变化如何影响抗原呈现,免疫抑制细胞和免疫检查点.
在PDAC中表观遗传疗法和组合的临床前和临床证据的摘要.

主要成果:

表观遗传变化抑制了抗原呈现,促进了免疫抑制细胞 (Tregs,MDSCs,TAMs),并上调了PDAC中的免疫检查点.
针对DNMT,HDAC,HMT或原蛋白的表观遗传疗法可以恢复免疫性和T细胞透.
结合表观遗传调节剂与免疫疗法或向药物的组合,有望将"冷"的PDAC瘤转化为"热"的响应性瘤.

结论:

表观遗传重编程提供了一种有希望的策略,通过增强抗瘤免疫力来克服PDAC免疫抵抗.
组合疗法,预测生物标志物和对表观遗传调节的更深入理解对于临床翻译至关重要.
将表观遗传调节与免疫疗法和向向方法相结合,可能会重新定义PDAC治疗策略.

关键词:

表观遗传变化表观遗传变化表观遗传疗法是一种表观遗传疗法.免疫细胞是免疫细胞.免疫治疗是一种免疫疗法.胰腺管道腺癌瘤瘤微环境是一个微环境.

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