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Updated: Feb 24, 2026

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在南极牙鱼Dissostichus mawsonichus中的4-氨酸肝素的双重功能特性

Mingli Liu^1,2, Ruiqin Hu^1,2, Wanying Zhai^1,2

¹Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China.

Journal of fish diseases

|February 22, 2026

概括

南极牙鱼的hepcidin (dm_4cyshep) 保留了抗微生物和铁调节功能,尽管其氨酸残留物较少. 这种独特的鱼类肝素变体显示出增强水产养殖中抗病能力的潜力.

科学领域:

生物化学生物化学
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

肝素是铁平衡的关键调节剂,也是脊椎动物中的抗菌性.
规范性肝素有八个氨酸残留物,形成二硫化键,以保持结构稳定.
在南极牙鱼 (Dissostichus mawsoni) 中发现了一种新型的肝素变体 (dm_4cyshep),具有四种囊氨酸残留物.

研究的目的:

为了研究独特的dm_4cyshep的抗菌和铁调节功能.
评估鱼类的结构和功能多样性.
探索dm_4cyshep在水产养殖疾病耐药性方面的潜力.

主要方法:

最低抑制度 (MIC) 测定以确定抗微生物活性.
流细胞计分析以评估结和杀菌效应.
在缺乏肝素的斑马鱼模型中过度表达dm_4cyshep以评估铁的调节.

主要成果:

dm_4cyshep表现出结合亲和力和杀菌活性,对抗格拉姆阳性和格拉姆阴性细菌.
对不同细菌菌株观察到不同的MIC值,表明了特定的抗微生物疗效.
在斑马鱼中过度表达dm_4cyshep显著减少了全身铁积累,证实了其铁调节作用.

结论:

dm_4cyshep保留了重要的抗微生物和铁调节功能,尽管氨酸含量减少了.
这种变体突出了鱼类肝素的结构和功能可塑性.
dm_4cyshep是增强水产养殖环境中抗病能力的有希望的候选物.

关键词:

南极牙鱼南极牙鱼抗菌是一种抗菌.四个囊蛋白的变体.肝素是一种肝素.铁调节器铁调节器铁调节器

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