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通过人工老化调节三种红色纹身颜料的毒性

Lise Aubry¹, Marie Blanchemanche¹, Lucie Breuillé¹

¹Univ. Grenoble Alpes, CEA, CNRS, Grenoble INP, IRIG, SyMMES, F-38000 Grenoble, France.

Chemical research in toxicology

|February 22, 2026

概括

纹身颜料,特别是红色的颜料,可能会在皮肤中降解,释放出有害的纳米粒子. 一些红色纹身颜料 (PR122) 在光降解时释放有毒产品,而其他颜料则被蛋白质稳定.

科学领域:

皮肤病学皮肤病学
毒理学毒理学毒理学
纳米技术纳米技术

背景情况:

纹身颜料被故意引入皮肤,创造了一个独特的长期暴露场景.
越来越多的证据表明,纹身颜料,尤其是红色,与皮肤疾病和潜在的癌症有关.
纹身颜料的降解和随后的纳米颗粒或可溶性产品释放到表皮层是令人担忧的.

研究的目的:

为了研究纹身中的色素降解途径.
评估纹身色素降解产品对人类角质细胞的毒理影响.
测试假设皮肤中的色素降解导致纳米粒子或可溶性产品释放,影响表皮细胞的假设.

主要方法:

纹身颜料的物理化学表征.
使用HaCaT人类角质细胞细胞系进行毒理学评估.
在模拟的光体环境中对色素光降解和降解的研究.

主要成果:

颜料红色122 (PR122) 在光降解时释放有毒的光产品,与颜料红色254 (PR254) 不同.
在重建的法哥利索姆介质中没有观察到色素降解.
免疫球蛋白抑制了色素细胞毒性,这表明蛋白质冠状形成减少了细胞毒性.

结论:

纹身色素降解途径,包括光降解,可以产生有毒物种.
蛋白质相互作用,如冠状形成,可以减轻纹身颜料的细胞毒性.
需要进一步的研究,以了解纹身颜色降解在体内对健康的长期影响.

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