晚期非小细胞肺癌 (NSCLC) 的经济负担:一个系统的文献审查
Nick Jovanoski1, Gavneet Kaur2, Hemlata Shukla2
1F. Hoffmann-La Roche, Basel, Switzerland.
Journal of medical economics
|February 22, 2026
概括
患有晚期非小细胞肺癌 (NSCLC) 的患者经历了高水平的医疗保健资源利用率和巨额成本. 大脑转移显著增加了这些负担,免疫疗法显示成本低于化疗.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 公共卫生 公共卫生
背景情况:
- 晚期非小细胞肺癌 (NSCLC) 是一个重大的经济挑战.
- 了解经济负担对于资源配置和患者护理策略至关重要.
研究的目的:
- 系统地审查高级 (IIIB/C/IV阶段) NSCLC 的经济负担.
- 确定影响医疗保健资源利用率 (HCRU) 和成本的因素.
主要方法:
- 从2011年开始对出版物的系统审查.
- 搜索发现了报告HCRU (住院,访问,测试) 和直接/间接成本的研究.
- 数据提取的重点是经济结果和影响因素.
主要成果:
- 晚期NSCLC患者表现出高HCRU,包括频繁住院和门诊.
- 直接成本因国家而异,美国,韩国,德国和英国的成本最高.
- 药物成本,门诊和住院费用是主要的成本驱动因素;免疫疗法与化学疗法相比,HCRU和成本较低.
结论:
- 晚期NSCLC患者面临着显著的HCRU和经济成本,受大脑转移和治疗类型等因素的影响.
- 在脑/中枢神经系统转移的患者中,成本和HCRU显著更高.
- 可比性受到货币差异和研究异质性的限制;需要进一步进行定量综合.
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