由致病性Burkholderia引起的人类感染:当前的临床挑战和未来的前景
Helal F Hetta1, Zinab Alatawi2, Salwa Q Bukhari3
1Division of Microbiology, Immunology and Biotechnology, Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia. hhussen@ut.edu.sa.
致病性Burkholderia物种如Burkholderia mallei,Burkholderia pseudomallei和Burkholderia cepacia复合体 (Bcc) 导致人类严重感染. 它们的本质抗微生物耐药性和毒性带来了重大诊断和治疗挑战.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 伯克霍尔迪亚属包括环境细菌,其中B. mallei,B. pseudomallei和Bcc是人类显著的病原体.
- 这些细菌会导致严重的感染,如腺和乳腺炎,并对免疫力低下的人和患有囊性纤维化的人构成风险.
研究的目的:
- 审查当前有关致病性Burkholderia物种的知识.
- 专注于流行病学,致病性,诊断和治疗方面的挑战.
- 确定研究缺口和未来方向.
主要方法:
- 现有微生物学,临床和基因组研究的叙事综合.
- 整合有关致病性Burkholderia物种及其管理的数据.
主要成果:
- B. mallei 引起动物性感染腺体; B. pseudomallei 引起乳腺炎,特别是在糖尿病患者中.
- 在囊性纤维化和慢性颗粒性疾病患者中,BCC导致严重的后果,导致疫情爆发.
- 这些病原体具有动态的基因组,表现出毒性,并且对多种抗微生物药物具有内在的耐药性.
- 诊断方面的进步包括分子技术,质谱学和全基因组测序.
- 由于多药性耐药性,治疗很困难,需要长时间的治疗方案.
结论:
- 具有临床意义的Burkholderia物种由于毒性和抗菌素耐药性,造成了主要的诊断和治疗障碍.
- 加强诊断,优化治疗和预防研究对于减轻临床影响至关重要.
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