结直肠癌查与70岁以上患者的存活率之间的关联:全国多中心回顾性研究的结果
Matteo Rottoli1,2, Giacomo Calini1,2, Giovanni Castagna1,2
1Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Journal of surgical oncology
|February 22, 2026
概括
70岁以上患者的结肠直肠癌 (CRC) 查显著降低了30天死亡率和并发症. 坚持CRC查计划可以改善老年人手术结果和瘤结果.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 外科手术的结果
背景情况:
- 大肠直肠癌 (CRC) 查通常推给50-70岁的人.
- 70岁以上患者的查实施不一致.
- 这项研究调查了CRC查对老年人手术结果的影响.
研究的目的:
- 分析70岁以上患者的CRC查和术后死亡率之间的关联.
- 评估70岁以上的查和未查的CRC患者的外科和瘤结局.
- 确定CRC查在老年外科患者群体中的好处.
主要方法:
- 一个国家数据库 (2018-2021) 的回顾性分析,包括10346名70岁以上接受CRC手术的患者.
- 患者被分为"查"和"没有查"组.
- 对混因素进行调整后勤回归分析,以评估30天死亡率,手术紧急性,并发症率 (Clavien-Dindo ≥ III),晚期,R0切除和停留时间等结果.
主要成果:
- 查CRC与显著降低30天死亡率 (OR 0.41) 和减少紧急 (OR 0.06) 和息性手术 (OR 0.32) 的比例有关.
- 查的患者出现的严重并发症较少 (Clavien-Dindo ≥ III,OR 0.69) 和癌症的晚期较小 (OR 0.53).
- 查增加了R0切除率 (OR 3.15) 和腹腔镜手术 (OR 1.93),结果在调整后的模型中一致.
结论:
- 对70岁以上接受CRC手术的患者,CRC查显示了显著的益处.
- 查与改善生存率,减少并发症和更好的外科手术结果有关.
- 建议鼓励和标准化对70岁以上的个人进行CRC查.
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