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抵抗训练部分恢复了骨肌肉氨基酸载体的年龄相关差异 - - 从两个随机对照试验的二次分析

E Lander¹, H Hamarsland², M J Lees³

¹Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.

The journal of nutrition, health & aging

|February 22, 2026

概括

抵抗训练和蛋白质摄入增加了年轻人和老年人的肌肉质量和力量. 运动部分扭转了与年龄相关的氨基酸载体的变化,支持肌肉健康.

科学领域:

运动生理学运动生理学
衰老研究研究衰老研究
营养生物化学营养生物化学

背景情况:

饭后肌肉蛋白质合成依赖于氨基酸 (AA) 的可用性和跨膜AA转运体 (AAT).
在久坐和老龄化的人群中,AA运输可能会受到损害.
了解AAT与年龄相关的差异对于优化肌肉健康至关重要.

研究的目的:

为了比较年轻人和老年人之间的骨肌肉AAT概况.
研究抵抗训练和蛋白质补充剂对两年龄组AAT的影响.
为了确定运动干预措施是否可以减轻与年龄相关的肌肉AA运输的下降.

主要方法:

两项随机对照试验的二次分析,涉及年轻 (20-45岁) 和年长 (70-80岁) 的成年人.
参与者进行了11-12周的全身抵抗训练,并补充了蛋白质.
骨肌肉活检 (m. vastus lateralis) 用西方斑点和免疫光学分析了AAT蛋白水平 (LAT1,LAT3,CD98,SNAT9).

主要成果:

抵抗训练在年轻人和老年人中增加了瘦腿质量和腿压力.
与年轻人相比,老年人表现出更高的基线膜SNAT9和LAT1.
训练诱导了LAT3和CD98的年龄相关变化,并且通常减少LAT1和SNAT9膜表达,同时增加核CD98.

结论:

抵抗训练与蛋白质补充剂相结合,可以改善肌肉质量,力量,并调节AAT配置文件.
运动干预可以部分抵消肌肉氨基酸运输中与年龄相关的变化.
这些发现对在整个衰老过程中保持肌肉健康和功能具有重大意义.

关键词:

衰老的衰老衰老的衰老氨基酸运输体是氨基酸运输体.合成代谢的耐药性合成代谢的抵抗性肌肉活检肌肉活检阻力训练阻力训练阻力训练

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