电纤维膜具有三重协同效应,用于癌症治疗
Xia Li1, Congyan Wu2, Jielong Luo2
1State Key Laboratory of Resource Insects, Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, Southwest University, Chongqing, 400715, China; Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile, College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing, 400715, China; College of Textile and Apparel Engineering, Xin Jiang Institute of Light Industry Technology, Xinjiang, 830021, China.
这项研究开发了一种新型的三重疗法纤维膜,使用丝纤维素 (SF),聚 (乳酸-co-甘油酸) (PLGA),绿色氨酸 (ICG) 和多克索鲁比辛化 (DOX),用于增强癌症治疗. 膜表现出光热,光动力学和化疗效应,显著抑制瘤生长.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 瘤复杂性需要组合疗法以提高疗效.
- 目前的单一治疗方法在解决瘤异质性方面存在局限性.
研究的目的:
- 开发一种多功能纤维膜,用于协同作用的三重癌症治疗.
- 为了研究开发的材料的联合光热,光动力学和化疗效应.
主要方法:
- 丝纤维素 (SF),聚 (乳酸-co-甘油酸) (PLGA),绿色 (ICG) 和多克索鲁比辛化物 (DOX) 的电,以创建纤维膜.
- 评估光热特性,反应性氧物种 (ROS) 生成和药物释放动力学.
- 对HepG2和B16细胞的细胞毒性的体外评估.
- 在体内研究评估瘤生长抑制.
主要成果:
- SF/PLGA/ICG/DOX膜显示出显著的光热转换,在近红外 (NIR) 辐射下,20分钟内温度增加43.9°C.
- NIR照射诱导了ROS生成和多克索鲁比辛化 (DOX) 的受控释放,导致瘤细胞的有效亡.
- 三重协同疗法在体内显著抑制瘤生长,并在体内根除了HepG2和B16细胞.
结论:
- 电SF/PLGA/ICG/DOX膜通过结合光热,光动力和化疗,为局部癌症治疗提供了一个有希望的策略.
- 这种多功能材料显示出在癌症治疗中增强治疗结果的巨大潜力.
更多相关视频
11:26Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall
Published on: July 31, 2015
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
相关概念视频
The Tumor Microenvironment
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy
