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Updated: Feb 24, 2026

Quantifying Agonist Activity at G Protein-coupled Receptors
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新型潜在的PPARα激动剂的设计,合成和活动评估

Xiaoqian Wang1, Weinan Wang2, Jixuan Guo3

  • 1School of Chemical Engineering, Sichuan University of Science & Engineering, Zigong 643000, China; Zhejiang Key Laboratory of Intelligent Drug Discovery and Development, School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, UCAS, Hangzhou 310024, China.

Bioorganic & medicinal chemistry
|February 22, 2026
PubMed
概括

研究人员确定了针对氧酶增殖器激活受体α (PPARα) 的新型化合物,用于治疗代谢疾病. 化合物GJX-230显示出高活性,对HMGCS2进行上调,并为开发更安全的PPARα激动剂提供了潜力.

关键词:
药物设计 药物设计这是一种PPARα激动剂.结构修改是指结构的修改.综合合成 综合合成

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