微塑料生物膜对抗抗生素耐药性基因水平转移在水环境中的对抗作用
Guosheng Zhang1, Dawei Zhang1, Weiying Li1
1State Key Laboratory of Water Pollution Control and Green Resource Recycling, College of Environmental Science and Engineering, Tongji University 200092, Shanghai, China; Jiaxing Key Laboratory of Environmental Risk Source Identification and Control, Jiaxing-Tongji Environmental Research Institute, 1994 Linggongtang Road, Jiaxing 314051, Zhejiang Province, China.
Aquatic toxicology (Amsterdam, Netherlands)
|February 22, 2026
概括
微塑料生物膜可能会令人惊地抑制抗生素耐药性基因转移,这与之前的研究相反. 这项研究揭示了微塑料生物膜如何与纳米和自由酸等环境因素相互作用,从而影响抗生素耐药性的传播.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 环境化学环境化学
背景情况:
- 水生环境中的微塑料含有生物膜,集中了抗生素耐药细菌 (ARB) 和基因 (ARG).
- 水平基因转移 (HGT) 是ARG传播的关键机制,通常由生物膜促进.
- 有限的研究存在于微塑料生物膜对ARG结合的影响.
研究的目的:
- 研究纳米和自由酸 (FNA) 对悬浮细菌中的ARG结合和微塑料生物膜的影响.
- 阐明微塑料生物膜在不同的环境条件下调节ARG结合频率的机制.
主要方法:
- 在悬浮细菌和微塑料生物膜中对ARG结合频率的比较分析.
- 暴露于特定度的纳米 (5.0 mmol/L) 和FNA.
- 已知影响ARG结合的环境因素的评估.
主要成果:
- 微塑料生物膜显著降低了纳米对ARG结合的促进作用.
- 微塑料生物膜减少了FNA的抑制作用,导致与悬浮细菌相比,结合频率更高.
- 微塑料生物膜在调节ARG结合方面发挥了双重作用,抑制了纳米的促进,同时减少了FNA的抑制.
结论:
- 微塑料生物膜可以抑制ARG结合,这与生物膜促进HGT的一般假设相矛盾.
- 微塑料生物膜与纳米和FNA等环境因素之间的相互作用影响了ARG传输动态.
- 这些发现为微塑料在抗生素耐药性传播中的复杂作用提供了新的见解.
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