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低剂量配方的连续双螺丝湿颗粒:工艺变量和API/粘合剂添加方法对颗粒质量属性的影响

Louis Bouckaert1, Mathieu Ombecq1, Giorgia Adamo1

  • 1Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

International journal of pharmaceutics
|February 22, 2026
PubMed
概括

为低剂量药物优化双螺丝湿颗粒 (TSWG) 非常重要. 较高的液体/固体比率和螺丝速度提高了颗粒大小和API统一性,尽管API湿度存在挑战.

关键词:
添加API/粘合剂的方法分区分析是分区分析.连续制造 连续制造制造设计实验的设计.低剂量配方是一种低剂量配方.双螺丝湿颗粒制造的双螺丝制造权重平均值绝对偏差的权重平均值.

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