气体捕获材料用于损害控制
Paula K N Alves1, Ian C Sutton2, James D Byrne2
1Department of Surgery, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
Advanced drug delivery reviews
|February 22, 2026
概括
像氧化 (NO),一氧化碳 (CO) 和硫化 (H2S) 这样的气体传递物显示出治疗的前景. 使用水凝,泡和固体的新输送方法增强了它们对各种疾病的临床应用.
科学领域:
- 生物化学和药理学 生物化学和药理学
- 翻译医学是一种翻译医学.
- 生物材料科学 生物材料科学
背景情况:
- 气体传递物 (氧化,一氧化碳,硫化) 是内生信号分子,调节重要的细胞过程.
- 这些气体影响心血管,免疫和神经系统功能,在癌症和败血症等疾病中具有治疗潜力.
- 由于高度的毒性,安全的,有针对性的气体传递存在挑战.
研究的目的:
- 审查目前提供气体传递物的策略 (NO,CO,H2S).
- 讨论气体传递物的机制,组织分布和反应性.
- 突出新型传递方法的临床实用性和翻译相关性.
主要方法:
- 对气体传递器输送系统的当前文献的综述.
- 对NO,CO和H2S输送的水凝,泡和固体配方进行分析.
- 关于气体传递剂的临床前和临床研究的讨论.
主要成果:
- 目前正在开发用于NO,CO和H2S的各种输送系统 (水凝,泡,固体).
- 这些系统有助于通过皮肤和肠道屏障传递,利用气体扩散.
- 优化给药,剂量和特异性对于治疗疗效至关重要.
结论:
- 气体传递剂的受控外源注射提供了显著的治疗潜力.
- 先进的交付策略对于克服临床翻译方面的挑战至关重要.
- 对优化输送方法的进一步研究将增强气体传递剂作为治疗剂的使用.
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