强迫症障碍中的区域小脑体积测量:一个ENIGMA-OCD研究
Srinivas Balachander1, Janardhanan C Narayanaswamy2, Venkataram Shivakumar3
1OCD Clinic, Department of Psychiatry, National Institute of Mental Health And Neurosciences (NIMHANS), Bangalore, India.
强迫症 (OCD) 与成年人的小脑体积较小有关,特别是大脑髓体和第七叶片b. 药物状态显著影响所有年龄段的小脑区别.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
背景情况:
- 皮质 - 条状 - thalamo - 皮质 (CTSC) 电路是理解强迫症 (OCD) 的关键.
- 新出现的证据表明,小脑参与强迫症,但之前的研究有局限性.
研究的目的:
- 在不同年龄组中,与健康对照组 (HC) 相比,研究强迫症患者的小脑亚区域体积.
- 为了确定与强迫症相关的小脑中的潜在神经解剖学差异.
主要方法:
- 来自ENIGMA-OCD工作组的个人参与者数据的大型分析.
- 利用了1,954名强迫症患者和2,091名高强迫症患者的结构性MRI扫描.
- 使用ACAPULCO管道进行大脑小粒区分,并使用ComBat协调体积测量.
主要成果:
- 与HC相比,患有强迫症的成年人在骨髓体和双边叶片VIIb中显示出明显较小的体积.
- 在FDR校正后,在儿科或青少年样本中没有发现显著的小脑体积差异.
- 药物状态在所有年龄组显著缓和小脑亚区域体积.
结论:
- 新发现表明,在整个发育过程中,特定的小脑子子区域与强迫症有关.
- 药物状态是影响强迫症小脑差异的关键因素.
- 对这些小脑发现的功能意义的进一步研究可能为强迫症治疗提供转化见解.
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