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在患有双相情感障碍的青少年中,悲伤快乐情绪转换期间的异常大脑活动:功能性MRI研究

Lin Wang¹, Liying Shen¹, Feifei Wu²

¹Clinical Psychology Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan, P R China.

Behavioural brain research

|February 22, 2026

概括

患有双相情感障碍 (BD) 的青少年表现出大脑活动的改变,特别是在调节情绪和认知的网络中. 这些发现可能有助于确定儿童BD个性化治疗的生物标志物.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
发展心理学发展心理学

背景情况:

患有双相情绪障碍 (BD) 的青少年经历了显著的情绪波动和认知缺陷.
青少年BD中情绪转换背后的神经机制尚不清楚.

研究的目的:

在患有BD的青少年中调查情绪切换的神经相关性.
确定青少年BD的潜在神经成像生物标志物.

主要方法:

在43名患有BD的青少年和18名健康的对照者 (HC) 中使用功能磁共振成像 (fMRI) 与情绪化的Go/No-Go任务.
分析神经成像数据使用一般线性模型与FDR校正.
使用FDR校正比较行为和临床数据.

主要成果:

与HC相比,患有BD的青少年在默认模式网络 (DMN) 中呈现过度活化,在突出网络和小脑中呈现低活化.
DMN过度激活与较差的任务性能相关 (遗漏率,反应时间).
减少岛内,时间和小脑活动,与抑制控制和执行功能受损有关.

结论:

患有BD的青少年在情绪调节,注意力转移和认知控制网络方面表现出异常的大脑活动.
识别的网络变化可以作为青少年BD的神经成像生物标志物.
这些发现支持针对儿科BD情绪认知功能障碍的向治疗.

关键词:

去/不去的任务范式.青少年双相情感障碍青少年双相情感障碍认知功能认知功能默认模式网络模式默认模式网络模式情绪调节情绪调节功能磁力共振成像 (fMRI) 是一种功能共振成像.

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