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Updated: Jul 2, 2026

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

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实验模型和方法,用于感染黄金葡萄球菌 (Staphylococcus aureus) 的伤口模型.

Estela Pérez1, Guillermo Landa2, Isabel Bescós3

  • 1Department of Animal Pathology, University of Zaragoza, Zaragoza, Spain.

Methods in cell biology
|February 22, 2026
PubMed
概括

这项研究介绍了一种新的小鼠模型,用于感染不愈合的伤口,这对于了解伤口愈合病理和开发新治疗方法至关重要. 这项研究有助于探索感染.

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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...