分析肌肉质量及其与骨密度和肥胖的关系,来自新墨西哥州的儿科尸检样本
Ethan C Hill1, Kathryn E Coakley2, Bria Riggs1
1Department of Orthopaedics and Rehabilitation, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
概括
儿童和青少年的肌肉质量与骨健康和代谢功能障碍有关. 较高的肌肉质量和密度与更好的骨矿物密度相关,而较低的肌肉质量与男性的代谢功能障碍相关的脂肪性肝病有关.
科学领域:
- 儿科健康 儿科健康
- 肌肉骨健康 肌肉骨健康
- 代谢健康 代谢健康
背景情况:
- 肌肉质量指标是身体活动和健康的重要指标.
- 这些指标在儿科患者群体中未得到充分研究.
- 这项研究研究了肌肉质量与骨密度和儿童和青少年肥胖的关系.
研究的目的:
- 调查骨肌面积和密度与骨矿物质密度 (BMD) 和儿童尸检样本中的肥胖相关因素之间的关联.
- 探索与代谢功能障碍相关的脂肪性肝病 (MASLD),性别,种族/种族以及死亡年龄的关系.
主要方法:
- 对5至20岁至99岁个体的死后计算机断层扫描 (PMCT) 数据的分析.
- 测量骨肌指数 (与身高相对的肌肉面积) 和肌肉密度 (Hounsfield单位) 对于大心肌和大腿肌.
- 多重线性回归以评估与骨硬度,肥胖,MASLD,性别,种族/种族,年龄和死亡方式的关系.
主要成果:
- 骨肌的指数和密度与股骨BMD (综合性别) 和腰部BMD (女性) 有正相关.
- 较高的肌肉指数与肥胖有关;较高的肌肉密度与较低的皮下脂肪有关.
- 减少与男性MASLD相关的psoas肌肉指数;男性的肌肉指数高于女性.
- 与西班牙裔和非西班牙裔白人同龄人相比,美国原住民的肌肉指数较低.
结论:
- 肌肉质量与女性的骨健康有关.
- 肌肉质量与男性的MASLD负面相关.
- 早期的身体活动和结构因素显著影响肌肉骨健康的发展.
相关概念视频
00:55Skeletal Muscle Anatomy
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
01:17Gross Anatomy of Bone
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in adults, it...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:09Changes in the Appendicular Skeleton with Age
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...