在MARBLES前性队列研究中,早期婴儿肠道微生物群的影响和自闭症谱系障碍的晚期发展的混合证据
Jennie Sotelo-Orozco1, Diana H Taft2,3, Jassim Al-Oboudi2
1Department of Public Health Sciences, University of California Davis, Davis, California, USA.
概括
早期婴儿肠道微生物组合显示了与晚期神经发育结果相关的微妙差异,包括自闭症谱系障碍 (ASD). 需要对更大的队列进行进一步的研究,以确认这些早期微生物标记物.
科学领域:
- 微生物组研究的研究.
- 神经发育科学 神经发育科学
- 儿科卫生健康 儿科卫生健康
背景情况:
- 肠道微生物组在婴儿发育中起着至关重要的作用.
- 早期的微生物暴露可能会影响神经发育轨迹.
- 确定神经发育状况的早期生物标志物是关键的研究目标.
研究的目的:
- 调查早期婴儿肠道微生物组合和后来的神经发育结果之间的关联.
- 确定婴儿时期的微生物差异是否预测自闭症谱系障碍 (ASD) 的发展.
- 探索潜在的微生物生物标志物用于神经发育诊断.
主要方法:
- 在使用16S rRNA测序的MARBLES队列中对婴儿 (0-7个月) 的便样本进行分析.
- 在36个月左右使用黄金标准评估对神经发育状况 (ASD,非TD,TD) 的临床分类.
- 在诊断组之间比较肠道微生物多样性 (α和β) 和细菌种群丰富度.
主要成果:
- 在患有ASD/非TD的婴儿和典型发育 (TD) 的婴儿之间,在整体肠道微生物多样性或主要类型中没有发现显著差异.
- 观察到一种潜在的微妙差异:在多重比较调整之前,后来被诊断出ASD的婴儿显示出Veillonella和Flavonifractor属的水平略低.
- 这些微妙的微生物差异可能比诸如分娩方式和婴儿饮食等因素的影响要小.
结论:
- 根据目前的分析,早期婴儿肠道微生物组组成没有显示与以后的ASD诊断相关的显著差异.
- 细微的变化在特定的细菌属,如Veillonella和Flavonifractor可能需要进一步调查作为潜在的早期指标.
- 建议在较晚的婴儿时间点进行更大规模的队列研究和分析,以阐明肠道微生物组与神经发育之间的纵向关系.
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