小儿肥胖的肠-大脑相互作用障碍 (罗马IV):患病率和与炎症标志物的相关性
Antonio Colucci1, Mara Creoli1, Giuseppina Rosaria Umano1
1Department of Woman, Child, General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
概括
肠-大脑相互作用障碍 (DGBI) 影响超过三分之一的肥胖儿童,功能性便秘是最常见的. 改变胆汁酸水平和非酒精性脂肪肝疾病与该人群中的DGBIs有关.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
- 肠-大脑轴研究研究
背景情况:
- 肥胖越来越多地与肠-大脑相互作用障碍 (DGBIs) 有关.
- 在肥胖个体中观察到改变的炎症标志物.
研究的目的:
- 确定肥胖儿童中DGBI的流行率.
- 调查肥胖儿童与没有DGBIs之间的炎症标志物的差异.
主要方法:
- 200名肥胖儿童 (BMI z-score > +2 SD) 的横截面研究.
- 使用罗马四号标准评估的DGBIs,以及人体测量,实验室测试和胆酸 (BA) 水平.
- 对非酒精性脂肪性肝病 (NAFLD) 进行评估.
主要成果:
- 36.5%的肥胖儿童至少有一次DGBI,最常见的是功能性便秘 (70.4%).
- DGBI与血清BA水平的变化有显著的关联,特别是在青春期前的儿童中.
- 41.1%的患有DGBI的儿童也患有NAFLD.
结论:
- DGBIs在肥胖儿童中非常普遍,功能性便秘是最常见的.
- 改变的BA水平和NAFLD显示出与DGBIs的强烈关联,表明共享的代谢途径.
- 这些发现可能会为儿童肥胖症中DGBIs的未来诊断和治疗策略提供信息.
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