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在卢旺达治疗HBV的HIV-HBV同时感染者中因各种原因导致的死亡率:基于人口的队列研究

Jean Damascene Makuza^1,2,3,4, Michael Law^1,4, Joseph Puyat^1,5

¹University of British Columbia, School of Population and Public Health, Vancouver, British Columbia, Canada.

Journal of viral hepatitis

|February 22, 2026

概括

在卢旺达,因慢性乙型肝炎病毒 (HBV) 感染而接受治疗的人群中,艾滋病毒的同时感染显著增加了死亡风险. 密切监测同时感染的患者对于改善撒哈拉以南非洲的治疗结果至关重要.

科学领域:

传染性疾病传染性疾病
肝病学肝病学是一种肝病学.
公共卫生公共卫生

背景情况:

慢性乙型肝炎病毒 (HBV) 感染带来肝硬化和肝癌的风险.
人类免疫缺陷病毒 (HIV) 的同时感染会加剧HBV的进展和死亡率.
在撒哈拉以南非洲地区接受治疗的人群中,有关HIV/HBV同时感染影响的数据有限.

研究的目的:

为了评估在接受治疗的慢性HBV患者的全因死亡率.
评估HIV/HBV同时感染对该人口死亡率的具体影响.

主要方法:

使用卢旺达地区卫生信息系统2 (2016-2023) 的回顾性队列研究.
包括为HBV治疗的2岁以上的个体.
多级Cox比例危险回归分析了与HIV/HBV同时感染相关的死亡风险.

主要成果:

4843人接受HBV治疗 (3905人单一感染HBV,838人同时感染HIV/HBV).
总的粗死亡率:每1000人年 (PY) 的1.6.
艾滋病毒/HBV同时感染的死亡率较高 (3.3比每1000年1.1),并与全因死亡率增加有关 (aHR4.07).

结论:

在卢旺达,在接受HBV治疗的人群中,死亡率很低.
在接受HBV治疗的患者中,HIV同时感染显著增加了死亡风险.
强调需要对HIV/HBV同时感染的个体进行更密切的跟踪,并进一步研究HIV病毒载量抑制.

关键词:

治疗HBV治疗方法这是一种HBV/HIV联合感染.单一感染的HBV感染.所有原因的死亡率.基于人口的基于人口的基础.

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