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Updated: Jul 9, 2026

Optogenetic Stimulation of the Auditory Nerve
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Scrt1-iCreER:一种可诱导的小鼠模型,用于对I型螺旋结和耳核神经元的基因访问

Xiang Mengya1,2, Li Jian3, Fan Shuwen1,2

  • 1ENT Institute and Department of Otorhinolaryngology, EYE & ENT Hospital, Fudan University, Shanghai, 200031, China.

Molecular neurobiology
|February 22, 2026
PubMed
概括

研究人员创建了一个新的小鼠模型,用于精确研究听觉回路的基因. 这种工具允许对Scrt1表达细胞进行永久标记,特别是针对I型螺旋质神经元和耳核神经元.

关键词:
在SCRT1中,SCRT1是SCRT1.科克莱尔核复合体是一个复合体.膠質細胞是膠質細胞.内耳是指内耳的内部部分.螺旋性结节神经元的神经元

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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...