口腔状细胞癌的手术前活检中的内芽:与世卫组织分类相比的预后价值
R Keerthika1, Akhilesh Chandra1, Rahul Agarwal1
1Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Oral diseases
|February 22, 2026
概括
在口腔癌活检中,内芽 (ITB) 与不良预后的联系比世卫组织的分级更强. 这种标志物可能会改善口腔状细胞癌 (OSCC) 的治疗计划.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 癌症研究 癌症研究
背景情况:
- 口腔状细胞癌 (OSCC) 需要准确的预后标记,以便有效的治疗计划.
- 内芽 (ITB) 是一种本病学特征,在各种癌症中具有证明的预后价值.
- 这项研究调查了在手术前的OSCC活检中ITB的预后意义,并将其与世界卫生组织 (WHO) 的分级进行比较.
研究的目的:
- 评估内芽 (ITB) 在口腔状细胞癌 (OSCC) 手术前活检中的预后效益.
- 将ITB的预后相关性与世界卫生组织 (WHO) 在OSCC中建立的组织学分级系统进行比较.
- 评估ITB与OSCC中的临床病理参数和生存结果的关联.
主要方法:
- 分析了42个手术前的OSCC病例的雄心勃勃的队列.
- 内芽 (ITB) 根据国际瘤芽共识会议的标准对H&E染色部分进行了评估.
- 除了临床病理参数,还评估了无病生存率 (DFS) 和整体生存率 (OS).
主要成果:
- ITB阳性与先进的结节阶段,较高的瘤结节转移 (TNM) 阶段,增加的入侵深度,围神经入侵和外扩散 (p <0.05) 有显著的相关性.
- ITB阳性病例显著减少了DFS (p=0.023) 和OS (p=0.019).
- 世界卫生组织 (WHO) 的评分没有显示与生存结果的显著关联.
结论:
- 与世卫组织对这一OSCC队列的分级相比,内芽 (ITB) 与不良预后特征和生存结果的关联更强.
- 在手术前的OSCC活检中,ITB可以作为一个有价值的预后标志物,可能有助于治疗决策.
- 需要在更大的多中心队列中进行进一步的验证,以确认ITB在OSCC管理中的临床实用性.
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...