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相关概念视频

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

17.2K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
17.2K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

1.8K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
1.8K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

16.5K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
16.5K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

9.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
9.4K

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相关实验视频

Updated: Feb 24, 2026

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

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BiGCN通过整合单细胞转录组和BCR目录来学习B细胞的功能状态.

Xiao Liu1,2, Jianghao Huang1,2, Shasha Zhao1,2

  • 1State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai, China.

Small methods
|February 23, 2026
PubMed
概括

一种名为BiGCN的新方法集成了B细胞的转录和受体数据,揭示了隐藏的B细胞状态和功能. 这促进了对免疫调节和癌症等疾病的理解.

关键词:
BCR 距离距离 BCR 距离距离B细胞受体 (BCR) 是一种图形卷积网络 (GCN) 是一个图形卷积网络.集成嵌入式嵌入式在 scRNA-seqq 中.

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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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Reusable Single Cell for Iterative Epigenomic Analyses
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Reusable Single Cell for Iterative Epigenomic Analyses

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相关实验视频

Last Updated: Feb 24, 2026

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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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科学领域:

  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学
  • 系统医学 系统医学

背景情况:

  • B淋巴细胞 (B细胞) 对于免疫反应和疾病至关重要.
  • 分析B细胞多样性是具有挑战性的,因为单独的转录和B细胞受体 (BCR) 谱系分析.
  • 现有的方法很难完全整合这些不同的数据类型,以进行全面的B细胞表征.

研究的目的:

  • 开发一种新的计算方法,BiGCN,用于单细胞转录和BCR目录数据的综合分析.
  • 通过统一这些模式,使B细胞状态和克隆关系的高保真性表征成为可能.
  • 改善功能注释和对B细胞种群的生物学洞察力.

主要方法:

  • 开发了BiGCN,一种使用图形卷积网络 (GCN) 框架的方法.
  • 综合配对单细胞RNA测序 (scRNA-seq) 和单细胞BCR测序 (scBCR-seq) 数据.
  • 将BiGCN应用于各种数据集,包括传染病,自身免疫和癌症.

主要成果:

  • 在数据集成,功能注释和生物发现方面,BiGCN显著优于现有的方法.
  • 成功回顾了B细胞成熟和免疫球蛋白类切换轨迹.
  • 发现了以前未知的中间B细胞亚型和功能状态.

结论:

  • BiGCN为B细胞研究提供了一个多功能和强大的平台.
  • 该方法增强了B细胞状态和克隆动态的表征.
  • BiGCN加速了免疫学,癌症生物学和系统医学方面的发现.