增强粘液透和肠上皮质运输的甲基糖纳米颗粒通过表面修改
Dechu Chen1, Canfeng Chen1, Yee Ying Lee2
1China-Malaysia Belt and Road Joint Laboratory on Oil Processing and Safety, Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.
ACS applied materials & interfaces
|February 23, 2026
概括
修改的二甲基甘油固体脂质纳米颗粒 (DAG-SLNs) 通过改善粘液透和细胞吸收来增强口服的输送. 用聚多巴胺和聚乙烯甘醇进行表面修改是克服胃肠道障碍和增强抗炎作用的关键.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 生物活性的口服输送面临着来自胃肠道环境的挑战.
- 纳米粒子 (NP) 表面修饰对于克服这些障碍至关重要.
- 基于二甲基甘油 (DAG) 的固体脂质纳米颗粒 (SLN) 提供了改善口服药物递送的潜力.
研究的目的:
- 为了研究表面修改对DAG-SLNs的影响,以提高口服输送.
- 为了评估修改后的DAG-SLNs的粘液透和细胞吸收.
- 用优化的DAG-SLNs来评估亚麻环的输送效率.
主要方法:
- 用甘三酸盐 (TG) 和乙棕酸盐 (CP) 作为对照剂制造DAG-SLN.
- 用聚多巴胺 (PDA) 和聚乙烯糖醇 (PEG) 对DAG-SLN的表面修改.
- 对纳米粒子-素相互作用,粘液透,Caco-2/HT-29细胞吸收和抗炎功效的评估.
主要成果:
- PDA和PEG的修改减少了纳米粒子-氨酸的疏水相互作用,增强了透.
- 与TG和CPSLN相比,DAG-SLN表现出更好的粘液透率,这是由于表面疏水性较低.
- Caco-2/HT-29细胞通过脂质/洞穴介导的途径吸收颗粒.
- 通过与细胞表面基团的相互作用,PDA修饰促进了跨膜能力.
结论:
- 表面修改的DAG-SLNs显示显著增强了口服输送能力.
- 优化的脂质纳米载体可以克服粘膜壁垒并提高治疗效率.
- 这项研究为设计先进的脂质纳米载体用于口服的管理提供了基础.
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