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Updated: Feb 24, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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半生理学人群口服和静脉注射黄的药理学建模,以量化系统前代谢和肠肝循环

Cedric Lau1,2,3, Charlotte van Kesteren1, Robert M Smeenk4

  • 1Department of Clinical Pharmacy, Albert Schweitzer Hospital, Dordrecht, the Netherlands.

CPT: pharmacometrics & systems pharmacology
|February 23, 2026
PubMed
概括

口服 (PCM) 导致比静脉注射更快的代谢物形成,涉及肝脏和肠道代谢. 这项研究描述了PCM的药理动力学,包括两种给药途径.

关键词:
药物代谢 药物代谢进入肝脏循环的循环还原.帕拉西托摩尔是一种可怕的药物.药物指标 药物指标 药物指标 药物指标系统前预测系统.

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