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泌尿学试验没有显著的结果. 我们能从失望中提取意义吗?
Darcy Noll1,2, Peter Stapleton1,2, Michael O'Callaghan1,3,4
1Discipline of Medicine, University of Adelaide, Adelaide, Australia.
许多具有无意义结果的泌尿器科试验需要进一步调查. 应用概率比 (LR) 可以帮助解释这些发现,并识别报告中的潜在语言操纵 ("旋转").
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 临床试验 临床试验
- 生物统计学 生物统计学
背景情况:
- 随机对照试验 (RCT) 往往产生非统计学意义上的初级结果,这给解释带来了挑战.
- 传统的统计方法难以获得非显著的结果,需要使用替代分析方法.
- 语言操纵或"旋转"可以掩盖发表的研究中试验结果的真实含义.
研究的目的:
- 分析具有非显著初级结局的泌尿学试验.
- 应用概率比 (LR) 来对这些结果进行更细致的解释.
- 在报告这些研究中评估语言操纵 ("旋转") 的流行率和预测因素.
主要方法:
- 2018-2024年间发表的泌尿学RCT的横截面综述,主要结果不显著.
- 计算概率比率 (LR) 以对比每个结果的零假设和替代假设.
- 对摘要进行语言操纵 ("旋转") 的分析.
主要成果:
- 13%的结果显示对替代假设 (LR < 1) 的支持更强烈,建议进一步调查.
- 36%的结果为零假设提供了决定性的证据 (LR>100),表明不需要重复.
- 在41.5%的摘要中发现了语言操纵 ("旋转"),与影响因子和LR<1.0相关.
结论:
- 许多具有无意义结果的泌尿学RCT值得进一步研究,使用像LR这样的方法.
- 概率比 (LR) 为解释临床试验中非显著发现提供了一个有价值的工具.
- 意识和识别"旋转"对于精确的科学沟通在泌尿病学研究至关重要.
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