在男性的非典型大腿骨折后的死亡率
Colton Hoffer1, Wiliam Obremskey2, Binni Makker1
1Medical College of Georgia at Augusta University.
概括
与部或轴骨折相比,接受双酸盐治疗的男性的非典型骨折 (AFF) 显示5年死亡率较低. 然而,小样本大小可能会限制关于AFF死亡率差异的最终结论.
科学领域:
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 非典型的股骨骨折 (AFF) 是治疗骨质疏松症的长期双酸盐 (BP) 治疗的罕见并发症.
- 之前关于AFF死亡率的研究主要集中在女性身上,并包括有限的男性人口.
研究的目的:
- 为了研究和比较在双酸盐治疗后经历了AFF,关节骨折或典型的下/大腿骨轴 (ST/FS) 骨折的男性的死亡率.
主要方法:
- 来自退伍军人事务公司数据仓库与BP处方的男性的回顾性队列研究.
- 使用ICD代码进行骨折分类,并根据ASBMR 2014标准对AFF进行放射检查.
- 对人口统计数据,临床特征和BP暴露时间的分析.
主要成果:
- 在5年内,AFF的死亡率为30% (n=23),关节骨折为52% (n=4,591),ST/FS骨折为48% (n=225).
- 最初的12个月死亡率为AFFs的4%,关节骨折的25%和ST/FS骨折的15%.
- 考克斯比例模型显示,AFF与其他骨折类型之间的5年死亡率没有统计学上显著的差异,可能是由于AFF样本规模较小.
结论:
- 虽然观察到的死亡率表明男性AFF后的风险可能较低,但有限的AFF病例数量阻止了最终的结论.
- 需要对更大的男性队伍进行进一步的研究,以确认AFF对双酸盐使用者的其他骨折类型的潜在死亡益处.
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