丁酸-丁酸乳衍生物作为作物保护剂:合成,生物活性和分子对接研究
Rouxi Ye1,2, Liutao Bao3, Weiyang Ma1,2
1College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou, People's Republic of China.
Pest management science
|February 23, 2026
概括
新型的肉酸 - - 布丁二氧酸乳衍生物显示出其作为双作用作物保护剂的前景. 化合物III18有效地控制了虫和真菌病原体,提供了对抗农药耐药性的新策略.
科学领域:
- 农业化学 农业化学
- 有机合成 有机合成
- 农作物保护 农作物保护
背景情况:
- 农药耐药性需要具有多目标活性的新型化合物.
- 活性子系统组装策略用于设计肉酸-布二氧酸乳衍生物.
研究的目的:
- 设计和合成新型的肉酸-丁二氧酸乳衍生物.
- 评估这些衍生物的杀虫剂和抗真菌活性.
- 为了确定具有双重生物活性的化合物用于作物保护.
主要方法:
- 合成肉酸 - - 布丁二氧酸乳衍生物.
- 使用1H NMR,13C NMR和HRMS进行结构性表征.
- 对杀虫剂和抗真菌活动的系统评估.
- 分子对接分析以预测目标相互作用.
主要成果:
- 几种衍生品显示出强烈的杀虫活性对抗Aphis craccivora.
- 多种化合物表现出对Botrytis cinerea和Collettotrichum gloeosporioides的抑制作用.
- 化合物III18 (2-CH3) 显示双重活性:90.69%的杀伤率和1.202 mg/L的EC50对Botrytis cinerea.
- 分子对接表明,III18与真菌聚氨酸酶和昆虫碳酸酶相互作用.
结论:
- 肉酸 - - 布二氧酸乳衍生物是有前途的双重功能作物保护剂.
- 化合物III18的生物活性和预测目标为开发环保,多目标农药提供了洞察力.
- 这种类型的化合物为管理农业害虫和抗现有治疗方法的病原体提供了有价值的战略.
相关概念视频
01:15Carboxylic Acid Derivatives: Overview
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Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:
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01:11Nomenclature of Carboxylic Acid Derivatives: Amides and Nitriles
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Naming Amides
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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