在高血压阻塞性睡眠呼吸暂停患者中,COMISA的隐藏负担
Büşra Durak1, Duygu Özol2, Sema Saraç2
1Department of Pulmonology, Hitit University Faculty of Medicine, Çorum, Türkiye.
Anatolian journal of cardiology
|February 23, 2026
概括
伴随性失眠和睡眠呼吸暂停 (COMISA) 在阻塞性睡眠暂停 (OSA) 患者中显著增加了耐性高血压 (RH) 的风险. 治疗失眠可能会改善这些人的血压控制.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 高血压研究 高血压研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与高血压密切相关.
- 伴随性失眠和睡眠呼吸暂停 (COMISA) 是OSA患者的一个未被认可的疾病.
- COMISA对抗性高血压 (RH) 的独立贡献尚不清楚.
研究的目的:
- 调查高血压OSA患者中COMISA和RH之间的关联.
- 在这个人群中确定RH的独立预测因子.
主要方法:
- 对131名高血压OSA患者进行了回顾性横截面研究.
- 使用失眠严重程度指数 (ISI ≥15) 诊断COMISA.
- RH的定义是不控制血压,尽管≥3种抗高血压药物.
- 人口,临床和多睡眠数据的多重逻辑回归分析.
主要成果:
- 在高血压OSA患者中,COMISA的患病率为29.8%.
- 低血压的患病率为43.5%.
- COMISA (OR=5.26,P<0.001) 和男性性别 (OR=3.24,P=0.010) 是RH的独立预测因素.
- 年龄,AHI和BMI与RH没有显著关联.
结论:
- 在高血压的OSA患者中,COMISA显著增加了RH风险,独立于OSA的严重程度和肥胖.
- 在OSA中,COMISA代表了一个独特的心血管表型.
- 在OSA患者中查和治疗失眠可能会改善血压控制和心血管结果.
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