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Updated: Feb 24, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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DVMMHGNN:一个双视图多模态异构图神经网络,用于微生物信息化药物重定位的对比学习

Huan Li1, YingZhe Bai1,2, Yang Lv3

  • 1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China.

Journal of chemical information and modeling
|February 23, 2026
PubMed
概括

这项研究介绍了DVMMHGNN,这是一种用于药物重定向的新型计算框架,它集成了微生物数据. 它准确地预测了药物与疾病的关联,增强了制药开发策略.

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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method07:51

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The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
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Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

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Drug response models describe how pharmacological agents interact with biological systems to produce measurable effects. Baseline responses are inherent physiological activities without a drug significantly influencing the observed pharmacological outcomes. Depending on the drug response model employed, these baseline responses may combine with the drug's effect in either an additive or proportional manner.Additive Drug Response ModelIn the additive model, the drug effect is independent of the...
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