精液血细胞因子在生育不良的男性与生育不良的男性:一个系统的审查和元分析
Hannah E Lyons1, Cristina N Arriaran Scott1, Sarah A Robertson1
1Robinson Research Institute and School of Biomedicine, The University of Adelaide, Adelaide, SA, Australia.
Human reproduction update
|February 23, 2026
概括
血细胞因子含量升高,包括IL-6,TNF-alpha和CXCL8,与男性不孕症有关. 需要使用标准化方法进行进一步的研究,以澄清它们在男性生殖健康中的作用.
科学领域:
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 男性生育能力评估主要依赖于精液分析,这种分析在理解异常精子参数和预测生育结果方面存在局限性.
- 研究精液等离子体 (SP) 细胞因子为深入了解男性生殖健康的病理生理和预后洞察提供了潜在途径.
- 对于男性生育能力的SP细胞因子的临床意义和信息性仍然不清楚,缺乏建立的共识.
研究的目的:
- 进行系统性审查和元分析,检查男性生育状况与精液血细胞因子度之间的关联.
- 评估现有文献在识别与男性生育相关的特定SP细胞因子方面的充分性,与最新的世卫组织指南保持一致.
- 为了确定测量SP细胞因子是否可以提高男性生殖功能的评估超出传统的精液分析.
主要方法:
- 在主要数据库 (PubMed,科学网,Scopus,Embase) 进行了系统的文献搜索,截至2025年4月.
- 研究包括原始数据,比较SP细胞因子度在明确定义的不育男性与生育/常态精子对照.
- 经过严格的查,质量评估和数据提取后,选出了52项涉及8153名男性的研究.
主要成果:
- 在不孕男性的精液血中观察到高度的介质蛋白-6 (IL-6),瘤坏死因子-α (TNF-α) 和CXCL8,与肥沃对照者相比.
- 具体发现包括在不育个体中增加IL-6 (SMD 0.39),TNF-alpha (SMD 0.13) 和CXCL8 (SMD 0.24).
- 虽然IL-6呈现出高异质性,但TNF-alpha和CXCL8的异质性较低,根据研究质量或对照组组成没有发现显著的调节效应.
结论:
- 该研究确定了男性不孕症和IL-6,TNF-alpha和CXCL8.8的高精液血水平之间存在显著的关联.
- 目前尚不确定这些促炎细胞因子是否是影响生育的致病因素,还是仅仅是炎症标志物.
- 在未来的研究中,标准化的技术方法对于精确量化和识别额外的信息性细胞因子至关重要,以推进男性不孕症诊断.
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