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Updated: Feb 24, 2026

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM
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A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

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BLRM-EffTox:一个无的两阶段第1阶段贝叶斯逻辑回归设计,包含有效性-毒性权衡,以优化剂量

Xin Liu1, Cynthia Basu2, Arnab Kumar Maity3

  • 1Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, USA.

Journal of biopharmaceutical statistics
|February 23, 2026
PubMed
概括

这项研究引入了BLRM-EffTox,这是一个新的1期瘤学试验设计,它平衡了疗效和毒性,以找到最佳剂量. 它通过选择多个剂量来更好地选择治疗方法,优于传统方法.

关键词:
贝叶斯逻辑回归模型的贝叶斯逻辑回归模型.决策指数 决策指数剂量优化剂量优化有效性-毒性权衡权衡.最大的耐受剂量.无两阶段设计,无两阶段设计.

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