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在TBI中DTI的第二个十年:第2部分:对中度和重度TBI的系统审查

Molly F Charney¹, Simone Glajchen², Shawn Brain³

¹Department of Neurology, Columbia University Irving Medical Center, New York, NY, United States.

Frontiers in neurology

|February 23, 2026

概括

与对照组相比,扩散张力成像 (DTI) 在中度至重度创伤性脑损伤 (msTBI) 患者中显示出较低的分数异构 (FA). 这一发现在所有研究中都是一致的,与更糟糕的认知结果和损伤严重程度的增加有关.

科学领域:

神经成像是一种神经成像.
神经学神经学
公共卫生公共卫生

背景情况:

创伤性脑损伤 (TBI) 是一个重要的公共卫生问题,具有广泛的严重程度.
扩散张力成像 (DTI) 提供了超越传统神经成像的组织微观结构的先进见解.
本次审查侧重于2012-2022年中度至重度TBI (msTBI) 的DTI申请.

研究的目的:

在报告使用的第二个十年 (2012-2022) 期间,系统地审查在中度至重度TBI (msTBI) 中使用DTI的研究.
在此期间探索在msTBI研究中DTI应用的演变和范围.

主要方法:

按照PRISMA指南进行了一次系统的文献审查.
在主要的电子数据库 (PubMed/MEDLINE,Embase,Cochrane Library,Web of Science) 中进行了搜索.
该审查涵盖了从2012年到2022年9月28日发表的研究.

主要成果:

包括129项涉及9,609名患有msTBI的患者的研究.
与前十年相比,纵向研究显著增加 (25.6%对13%).
与对照组相比,msTBI患者的低分数异位性 (FA) 是一个一致的发现,与更糟糕的认知结果和更严重的损伤严重程度有关.

结论:

自2002-2012年以来,mSTBI中的DTI应用在数量和范围上得到了扩大.
纵向研究和全脑分析的数量显著增加.
下部FA仍然是最突出的发现,尽管研究异质,但在msTBI患者中始终观察到.

关键词:

在 DTI 中,DTI 是指DTI.这是一个TBI,TBI.认知认知认知神经成像是一种神经成像.审查审查审查审查审查审查

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