三胞胎症13作为由二氧化诱导的肺高血压的危险因素
Kazu Ishikawa1,2, Hiro Nakao1,2, Daisuke Shinjo3
1Center for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan.
Annals of pediatric cardiology
|February 23, 2026
概括
氧化物可以导致婴儿的肺高血压 (PH). 三胞胎症13显著增加这种风险,即使在低剂量和利尿剂,突出需要小心在受影响的新生儿.
科学领域:
- 儿科药理学 儿科药理学
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
背景情况:
- 氧化是超胰岛素性低血糖症的关键治疗方法.
- 肺高血压 (PH) 是一种严重的药物不良反应,与二氧化有关.
- 了解氧化物诱导PH的基线风险至关重要.
研究的目的:
- 为了确定在服用二氧化后发展肺高血压 (PH) 的基线风险.
- 为了确定在接受氧化物治疗的儿童中PH的危险因素.
主要方法:
- 对65名15岁以下的儿童进行了回顾性队列研究,这些儿童因先天性胰岛素高血症而接受氧化物治疗.
- 从电子医疗记录中提取的数据,重点关注PH发展和患者背景.
- 贝叶斯估计用于评估PH风险.
主要成果:
- 5%的儿童 (65人中3人) 患有PH.
- 三胞胎体13是一个显著的PH风险因素 (100%对0%,P<0.001).
- 低出生体重也与PH发育有关 (P = 0.049).
结论:
- 三胞胎症13显著提高PH的风险与二氧化使用.
- 预防性利尿剂和低剂量的氧化可能无法预防三症病13患者的PH.
- 建议在给患有三形状的婴儿和低出生体重的婴儿开处方diazoxide时谨慎使用.
相关概念视频
Pulmonary Hypertension: Classification and Pathogenesis
703
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
703
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
671
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
671
Pneumothorax-I
1.7K
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
1.7K
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
506
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
506
Pulmonary Embolism I: Introduction
942
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
942
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.9K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.9K


