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局部晚期直肠癌的全新辅助疗法:随机试验的临时结果.

Ravi Shankar Biswas1, Sulagna Das2, Dipankar Ray1

  • 1Department of Surgical Gastroenterology, Medical College Hospital, Kolkata, West Bengal India.

Indian journal of surgical oncology
|February 23, 2026
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总的新辅助疗法 (TNT) 在局部晚期直肠癌 (LARC) 中显著减少远程转移,与传统化疗放射疗法 (CRT) 相比,具有前景. 虽然病理完整反应率相似,但TNT可能会改善长期结果.

关键词:
拉尔克 (LARC) 是一个非常重要的组织.这是直肠癌.总的新辅助疗法治疗.

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科学领域:

  • 在瘤学瘤学.
  • 手术瘤学手术瘤学
  • 胃肠道瘤学 胃肠道瘤学

背景情况:

  • 局部晚期直肠癌 (LARC) 提出了传统化疗放射治疗 (CRT) 的治疗挑战.
  • 较差的病理完整反应 (pCR) 和远程转移的高率是标准CRT的常见情况.
  • 总的新辅助疗法 (TNT) 正在成为改善LARC结果的战略.

研究的目的:

  • 在LARC患者中比较TNT与常规CRT的疗效和安全性.
  • 评估TNT对实现pCR和减少远程转移的影响.
  • 评估二次终点,包括瘤回归和边际状态.

主要方法:

  • 一个开放的随机对照试验,涉及172名LARC患者.
  • 手臂A (TNT):手术前的CRT,然后进行三轮CapOx化疗.
  • 手臂B (CRT):手术前的CRT,然后进行六次辅助性CapOx化疗.

主要成果:

  • 对150名患者的中间分析显示了可比的pCR率 (16.2%对17.4%;p>0.05).
  • 在1年内,TNT组的远程转移病例显著减少 (6对16;p=0.040).
  • 在瘤回归,边缘状态或毒性方面没有观察到显著差异.

结论:

  • 在LARC中,TNT和传统的CRT产生类似的pCR率.
  • 一年后,TNT显著减少了远程转移,这表明系统控制得到了改善.
  • 在等待进一步的长期随访的情况下,TNT是LARC潜在的首选治疗策略.