相关实验视频

Updated: Feb 24, 2026

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

严重的大动脉狭窄和保存的喷射部分的流量梯度:10年跨导管大动脉置换研究

Prabhjot Hundal¹, Zaid Abood¹, Niloufar Javadi¹

¹Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers, Aurora Health Care, Milwaukee, Wisconsin.

Journal of the Society for Cardiovascular Angiography & Interventions

|February 23, 2026

概括

具有矛盾的低流量低梯度 (pLFLG) 大动脉狭窄症 (AS) 的患者在经过透气管大动脉置换 (TAVR) 后的1年生存率较差,但5年生存率与高梯度AS相似. 正常流低梯度 (NFLG) AS结果与高梯度 AS结果没有显著差异.

科学领域:

心脏病学心脏病学
干预心脏病学干预心脏病学
心脏外科手术心脏外科手术

背景情况:

对于正常流量低梯度 (NFLG) 和悖论性低流量低梯度 (pLFLG) 大动脉狭窄 (AS) 的长期结果存在有限的数据.
血动学亚型的AS可能会影响TAVR后的预后.

研究的目的:

为了比较1年和5年的全因死亡率,在三个血液动力学组中进行TAVR治疗严重症状AS的患者:高梯度AS (HGAS),NFLGAS和PLFLGAS.
阐明TAVR后不同AS血动力学模式的长期预后影响.

主要方法:

对1683名患有严重症状原生AS和保存左心室喷射分数的患者进行了回顾性分析,这些患者在2012年至2022年期间接受了TAVR.
患者被分为HGAS (平均梯度≥40毫米平),NFLG (中风体积指数≥35毫升/米2,平均梯度<40毫米平) 和pLFLG (中风体积指数<35毫升/米2,平均梯度<40毫米平) 组.
主要结局是TAVR后1年和5年评估的所有原因死亡率.

主要成果:

在1年后,PLFLG AS患者的死亡率比HGAS (10.8%,P=.05) 高 (15.5%).
NFLG AS显示出比HGAS更高的一年死亡率的趋势 (15.9%与10.8%,P=.06),但这在统计学上并不显著.
在TAVR后5年,在三个组中没有观察到生存的显著差异.

结论:

与HGAS AS相比,pLFLG AS患者在TAVR后的1年生存率较差,尽管5年生存率趋于一致.
在TAVR后1年或5年,NFLG AS和HGAS AS之间没有发现显著的生存差异.
这些发现强调了在评估TAVR结果时考虑特定AS血液动力学模式的重要性.

关键词:

高梯度的大动脉狭窄症正常流动低梯度的大动脉狭窄症矛盾的低流量低梯度的大动脉狭窄症.通过导管更换大动脉门.

更多相关视频

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

相关概念视频

Aortic Regurgitation I: Introduction

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

Aortic Regurgitation III: Medical Management

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...