男性伴侣以前患有结核病与重复流产 (RPL) 有关吗? - 一个单一中心的回顾性分析分析
Xin-Zhuan Jia1, Lan Wei2, Bo-Lin Zheng3
1Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Open medicine (Warsaw, Poland)
|February 23, 2026
概括
男性肺结核病史增加了异常性复发性妊娠丧失 (RPL) 的风险. 男性伴侣未经治疗的结核病与RPL特别相关,可能是由于精子DNA碎片化程度较高和水平较低.
科学领域:
- 生殖医学 生殖医学
- 男人不孕不育的情况
- 传染病对生殖的影响
背景情况:
- 异常性重复性妊娠损失 (RPL) 研究传统上侧重于女性因素.
- 新出现的证据表明,男性伴侣可能会导致不良妊娠结果.
- 男性结核病越来越多地与妊娠并发症有关.
研究的目的:
- 调查男性伴侣肺结核病史和怀孕早期异常性RPL之间的关联.
- 探索男性结核病在无法解释的重复妊娠流产中的潜在作用.
主要方法:
- 对182对具有异常RPL的夫妇和260对肥沃夫妇 (对照) 的回顾性研究.
- 后勤回归分析,以评估男性结核病史和RPL之间的相关性.
- 斯皮尔曼相关性用于分析结核病,精子DNA碎片化指数 (DFI) 和水平之间的关系.
主要成果:
- 在RPL组的男性伴侣中,先前肺结核的患病率更高 (37.91%).
- 与对照组相比,研究小组的精子DNA碎片化指数 (DFI) 显着更高 (17.52 ± 7.87与7.79 ± 4.49,p=0.000).
- 患有肺结核病史的男性伴侣,特别是未接受治疗的男性伴侣,患有RPL的风险明显更高 (p=0.000). 结核病的患病率与DFI正相关 (R=0.492,p=0.000) 和与丸激素负相关 (R=-0.120,p=0.012).
结论:
- 具有肺结核病史的男性伴侣,特别是未经治疗的男性伴侣,更容易患上异常性RPL.
- 在有肺结核病史的男性伴侣中,高DFI和低丸激素水平可能会导致RPL.
- 这项研究强调了考虑男性伴侣的健康状况,特别是结核病史的重要性,以应对复发性流产.
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